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尿激酶型纖溶酶原激活劑選購指南

更新時間：2016-11-01 點擊次數(shù)：2991

尿激酶型纖溶酶原激活物(Urokinase type Plasminogen Activator (uPA) )，uPA是一種絲氨酸蛋白水解酶。小鼠uPA基因位于第10條染色體長臂上，其長度為6.5KD，由11個外顯子構(gòu)成，可轉(zhuǎn)錄成24KB的成熟的mRNA，初始翻譯產(chǎn)物為前尿激酶原（含431個氨基酸殘基），除去20個氨基酸殘基的信號肽后即為細胞分泌的尿激酶原（pro-uPA），在158LYs位處劈裂，則成為由二硫鍵連結(jié)的雙鏈活性型結(jié)構(gòu)，即20×103的A鏈和34×103的B鏈。C端的A鏈包括一個Kringle區(qū)和表皮生長因子（EGF）功能區(qū)，表皮生長因子功能區(qū)能介導與特異的受體結(jié)合，去掉此功能區(qū)，其仍具有激活纖溶酶原作用，,但卻無與受體結(jié)合的能力。C端的B鏈有絲氨酸蛋白酶功能區(qū)，為uPA的活性中心。uPA的合成與分泌受諸多因素影響，如原癌基因V-Src、Ras、細胞因子TNF、INF、IL-1、TGF-β、IGF-1、FGF、基質(zhì)金屬蛋白酶等。一般說來，uPA主要在生理、病理條件下與細胞分化、遷移、組織重建、細胞周圍基質(zhì)降解有關(guān)。

尿激酶型纖溶酶原激活物(Urokinase type Plasminogen Activator (uPA) )，蛋白

貨號	品名	包裝	價格	品牌
ADG108	Urokinase-Receptor (uPAR), human, rec	200 µg	9725	American Diagnostica Inc
107	urokinase, human, single-chain (scuPA), frozen solution, dry-ice shipment	25 µg	6900	American Diagnostica Inc
ADG146NL	urokinase, human, amino terminal fragment (uPA-ATF), frozen solution, dry-ice shipment	1 mg	86375	American Diagnostica Inc
ADG146N	urokinase, human, amino terminal fragment (uPA-ATF), frozen solution, dry-ice shipment	0.1 mg	15500	American Diagnostica Inc
EZ005C	Urokinase type Plasminogen Activator (uPA)	1 x 100,000 units	4710	hyphen biomed
EZ005B	Urokinase type Plasminogen Activator (uPA)	1 x 10,000 units	1035	hyphen biomed
EZ00	Urokinase type Plasminogen Activator (uPA)	1 x 1,000 units	465	hyphen biomed
ADG125N	Urokinase (uPA), human, recombinant, LMW, frozen solution, dry-ice shipment	100 µg	9725	American Diagnostica Inc
ADG102	Urokinase (uPA), human, HMW	250,000 IU	詢價	American Diagnostica Inc
ADG100	Urokinase (uPA), human, HMW	10,000 IU	5000	American Diagnostica Inc
128	urokinase (uPA), human, HMW	100,000 IU	13452	American Diagnostica Inc
ADG244FN	SPECTROFLUOR® uPA	10 µmole	1850	American Diagnostica Inc

尿激酶型纖溶酶原激活物(Urokinase type Plasminogen Activator (uPA) )抗體

貨號	品名	包裝	價格	品牌
11651-05021	Urokinase (uPA), anti-human	150 ug	2800	AssayPro
11651-05011	Urokinase (uPA), anti-human	150 ug	2320	AssayPro
12172-05021	uPA, anti-rat	150 ug	2800	AssayPro
12172-05011	uPA, anti-rat	150 ug	2320	AssayPro
TC42000	u-PA purified protein, lyo. 125 µg	RUO	3941.28	Technoclone
TC31014	Polyclonal anti u-PA antibody (rabbit)1 mg	RUO	2650.98	Technoclone
TC31015	Polyclonal anti u-PA antibody (rabbit) 5 mg	RUO	4128.96	Technoclone
ADG3471	murine MAb against uPA-ATF (aa 17-34)	250 µg	3950	American Diagnostica Inc
ADG3689	murine MAb against uPA b-chain, affinity purified	250 µg	4475	American Diagnostica Inc
TC21063	Monoclonal anti u-PA antibody 4UK	RUO	4715.46	Technoclone
12171-05021	ATF-uPA, anti-mouse	150 ug	2800	AssayPro
12171-05011	ATF-uPA, anti-mouse	150 ug	2320	AssayPro
11661-05021	ATF uPA, anti-human	150 ug	2800	AssayPro
11661-05011	ATF uPA, anti-human	150 ug	2320	AssayPro

尿激酶型纖溶酶原激活物(Urokinase type Plasminogen Activator (uPA) )試劑盒

貨號	品名	包裝	價格	品牌
RK018A	ZYMUTEST uPA-PAI-1 complexes	Kit of 96 tests	7800	hyphen biomed
RK013A	ZYMUTEST uPA Antigen	Kit of 96 tests	7290	hyphen biomed
TC12010	u-PA ELISA Kit 96 T.	RUO	9196.32	Technoclone
TC16010	u-PA Combi Actibind ELISA Kit 96 T.	RUO	10603.92	Technoclone
894	IMUBIND® uPA ELISA	96 microwell plate	10704	American Diagnostica Inc
EU1001-1	Human Urokinase (uPA) ELISA Kit	96 well plate	4760	AssayPro
CU1001b	Human Urokinase (uPA) Chromogenic Activity Assay Kit (Indirect Assay)	96 well plate	6930	AssayPro
CU1001a	Human Urokinase (uPA) Chromogenic Activity Assay Kit (Direct Assay)	96 well plate	5530	AssayPro
899	FEMLE™ uPA/PAI-1 ELISA, - CE	2x96 microwell plates	詢價	American Diagnostica Inc

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